by glonq on 11/14/23, 6:50 PM
> Furthermore, aspirin can inhibit the progression of colorectal cancer
Cool! Might be too little too late for me, but hopefully this can help improve prognoses for other people soon.
by blakesterz on 11/14/23, 6:25 PM
by elromulous on 11/14/23, 6:44 PM
This is encouraging. As someone with ulcerative colitis, I'm at increased risk for colorectal cancer, and cannot take NSAIDs, due to them paradoxically causing flare ups.
by DoreenMichele on 11/14/23, 9:10 PM
Cool. Now let's identify the root cause of the tumors.
Based on some cancers being caused by viruses, I'm guessing viruses would be a good place to start looking.
by candiddevmike on 11/14/23, 6:52 PM
Don't read this and start taking daily aspirin without talking to your doctor. Aspirin isn't like a vitamin, it can cause serious problems with daily usage.
by car on 11/14/23, 7:29 PM
"Aspirin induces the production of two tumor-suppressive microRNA molecules (miRNAs) called miR-34a and miR-34b/c. To do this, aspirin binds to and activates the enzyme AMPK, which in turn alters the transcription factor NRF2 such that it migrates into the cell nucleus and activates the expression of the miR-34 genes. For this activation to succeed, aspirin additionally suppresses the oncogene product c-MYC, which otherwise inhibits NRF2."
by antiviral on 11/14/23, 5:51 PM
"Colorectal cancer (bowel cancer) is the third most common form of cancer worldwide, with around 1.9 million newly diagnosed cases and 900,000 deaths every year. Therefore, preventive substances represent an urgent clinical need. Aspirin/acetylsalicylic acid has proven to be one of the most promising candidates for the prevention of colorectal cancer. Among other findings, studies have shown that when patients with cardiovascular diseases took low doses of aspirin over several years, it reduced their risk of colorectal cancer. Furthermore, aspirin can inhibit the progression of colorectal cancer. Now a team led by Heiko Hermeking, Professor of Experimental and Molecular Pathology at LMU, has investigated which molecular mechanisms mediate these effects."