from Hacker News

High levels of antihistamine drugs can reduce fitness gains

by bikenaga on 6/18/25, 2:37 PM with 4 comments

• by username44 on 6/18/25, 2:50 PM

  This is really interesting, as I came to a similar conclusion recently. I was taking famotidine (h2 blocker) and fexofenadine (h1 blocker) and noticed my daily running routine became significantly more difficult. Within a few days of stopping both, it became easier again.

• by AnthonBerg on 6/18/25, 2:51 PM

  Having had to figure out a physiological puzzle involving histamine as an alertness-promoting neurotransmitter, and getting to see adult-onset Type 1 diabetes up close where histamine is intimately related to everything as a core part of glucose metabolism – both these aspects of histamine are well known but surprisingly underdiscussed! — I have come to see histamine as sort of a “tissue opener” signal. And with all as the vantage point, the perspective afforded even just by the headline makes immediate and intuitive sense.

• by jameskilton on 6/18/25, 2:51 PM

  Important note, but still very interesting research!

  > Halliwill emphasized that the new studies and other related research use very high doses of antihistamines, much higher than what a person would consume to combat allergies. More evidence is needed to know whether a low-dose daily allergy medication could interfere with fitness.

• by UK-AL on 6/18/25, 2:46 PM

  Ma gains

  I have awful hay fever, so take them religiously.