from Hacker News

Immediate PB2-E627K amino acid substitution after single infection (...)

by greenavocado on 6/12/25, 3:26 PM with 22 comments

  • by Jtsummers on 6/12/25, 3:50 PM

    I've flagged this submission. The title is editorialized and indicates an event occurred which didn't (or at least is not supported by this paper). The South Korean lab did not make bird flu 100% lethal, they studied an in-the-wild bird flu and ran experiments on mice.

  • by hall0ween on 6/12/25, 3:46 PM

    After reading the abstract, this title seems to me like flame/click-bait.

    This test has been done in mice only (since no other animal was mentioned in the abstract).

    If one follows the scientific method, this means whatever conclusion the authors make can only be extended to mice. Extrapolation to “mammals” is not present in the abstract implicitly or explicitly.

  • by CBLT on 6/12/25, 3:47 PM

    The paper is interesting, but it doesn't seem to be supporting your title? I'm just past the part where they showed 100% infection rate in mice.

  • by xhkkffbf on 6/12/25, 3:45 PM

    What could possibly go wrong?

  • by ortusdux on 6/12/25, 3:44 PM

  • by close04 on 6/12/25, 3:47 PM

    The next era of MAD won't be with bigger bombs but with bio-weapons. Easier to disseminate, potentially deadlier than an entire arsenal of nukes, and maybe even more selective if it can be designed to be targeted or only one side has the vaccine.