from Hacker News

Daily Pill May Work as Well as Ozempic for Weight Loss and Blood Sugar

by uxhacker on 4/17/25, 10:59 AM with 71 comments

  • by uxhacker on 4/17/25, 11:02 AM

    Not just that the pill works as well as the jab, but Lilly has stockpiled over a billion pills to meet expected demand.
  • by bluesounddirect on 4/17/25, 11:35 AM

  • by Spooky23 on 4/17/25, 1:46 PM

    Duh. Rybelsus has been available for a couple of years, and is the legit source for the compounding pharmacies selling GLP drugs.

    The downside is that it you need to be disciplined taking it. First thing in the AM, empty stomach, no eating or drinking for a half hour.

  • by basisword on 4/17/25, 12:17 PM

    If obesity becomes treatable with a pill I'm really curious to see how it impacts the demand for healthcare, particularly in countries with free public health care. Could it cut the demand enough so that with current spending availability and quality of treatment can increase a meaningful amount?
  • by drcongo on 4/17/25, 12:38 PM

    Don't we already have this in pill form with Wegovy / Rybelsus? https://en.wikipedia.org/wiki/Semaglutide
  • by nerdjon on 4/17/25, 12:49 PM

    I can't read the article so I don't know if this is answered, but my real question is the price. Is it reasonable for the average person or is this for the rich only.

    More options are great, but not if most people that need it can't afford it.

    It is fascinating how quickly this space has evolved. Seems incredibly quick for medicine. That isn't a criticism, just things seem to generally move very slow.

  • by biophysboy on 4/17/25, 12:14 PM

    Considering that we spend 1% of the fed budget on dialysis alone, glp-1 may have come just in time...
  • by peppers-ghost on 4/17/25, 12:15 PM

    I wonder if this will make side effects more apparent. 7 doses a week vs. once a week with the shot.
  • by hkchad on 4/17/25, 6:33 PM

    Yea but whats the price? Even w/ insurance a lot of the GLP-1's are hundreds of $$/mo and most can't afford that outside of hollywood.
  • by colingauvin on 4/18/25, 2:17 AM

    There are still some problems with Orfo but it's definitely a step up from the peptide. After Pfizer killed Danuglipron, this is nice to see.
  • by joe_91 on 4/17/25, 11:59 AM

    Until they find out that there are unintended side effects...

    Better off just exercising and eating as clean as you can!