from Hacker News

Drinking alcohol reduces the body's natural GLP-1 activity by 34%

by comova on 10/11/24, 10:00 PM with 22 comments

• by comova on 10/11/24, 10:00 PM

  "These findings provide compelling evidence that acute alcohol consumption decreases GLP-1, a satiation signal, elucidating alcohol's 'apéritif' effect." This could increase hunger and cravings (including for more alcohol).

• by comova on 10/11/24, 11:33 PM

  And if you haven't asked a friend who's on one, taking a GLP-1 medication reduces drinking by about 50%:

  https://recursiveadaptation.com/p/first-ever-randomized-tria...

• by tiffanyh on 10/11/24, 11:56 PM

  Which is interesting because there’s a lot of Mediterranean cultures that drink after every meal (lunch & dinner).

  And the reason is “for digestion”.

  So this would suggest the opposite effect is happening. Drinking actually hurts digestion.

• by pedalpete on 10/11/24, 11:46 PM

  I was expecting to see this study as related to GLP-1 activity post a night of drinking, and therefore we'd understand the mechanism, as decreased sleep delays GLP-1 activity by 90 minutes (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697408/)

  I'd be keen to understand the pathway by which alcohol intake directly reduces GLP-1 activity.