from Hacker News

Type 2 diabetes drug associated with 35% lower risk of dementia, study finds

by monkey_monkey on 8/29/24, 9:44 AM with 42 comments

  • by hi-v-rocknroll on 8/29/24, 11:08 AM

    Article:

    - SGLT-2 inhibitors: canagliflozin, dapagliflozin, sotagliflozin, bexagliflozin

    - DPP-4 inhibitors: sitagliptin, saxagliptin, linagliptin

    Other beneficial drugs beyond/with/for diabetes and/or weight:

    - Metformin

    - AGIs: acarbose

    - GLP-1 agonists: tirzepatide, semaglutide, liraglutide

    - DACRAs: cagrilintide

    Maybe in the future it will be possible to manage a person's glucose and related hormone levels in roughly a continuous keto or borderline low blood sugar state using the equivalent of an "insulin pump" and a real-time blood glucose monitor control system such that it doesn't promote low-blood sugar neurological symptoms.

  • by chiefalchemist on 8/29/24, 9:59 AM

    The smarter way to look at it: Diabetes increases the chances of dementia. It's diabetes that's causing an unnatural increase. Rhe drug is simply a catalyst for something closer to normal. Obesity at it's current rate, while socially normalized, is from an evolutionary standpoint abnormal.

  • by tsoukase on 8/29/24, 12:34 PM

    Diabetes is a debilitating situation. A slow killer. It is an independent factor for both degenerative (Alzheimer's) and vascular dementia. I do not think any drug will be better than the disease itself. On the other side, if we use a diabetes drug to cure dementia in non-diabetes patients, we might have a good result but with hypoglycemia as a side effect.

  • by rawicki on 8/29/24, 11:48 AM

    DPP-4 drugs are less effective also on other metrics. Would be far more interesting to see the comparison of SGLT-2 inhibitors vs GLP-1 agonists.

    For some reason GLP-1 drugs are not that popular in Korea (and still not prescribed just for the weight loss), so that may explain why these researchers haven't done that.

  • by mgarfias on 8/29/24, 4:03 PM

    Mom has the dementia and I have t2d. I started looking and discovered one of the meds I’m on already is one of these sglt-2 deals. So yay!

  • by zug_zug on 8/29/24, 12:46 PM

    In people with diabetes.