from Hacker News

Lactate helps cancer cells resist chemotherapy

by assadk on 8/23/24, 10:27 PM with 24 comments

  • by cpncrunch on 8/23/24, 11:03 PM

    Neither this article, nor the actual paper it is based on (https://www.nature.com/articles/d41586-024-02731-9#:~:text=T....) has any mention of exercise, and the title here seems to be editorialised to add in "Metabolic byproduct of anaerobic exercise".

    Just because lactate is produced from anaerobic exercise and this study found that lactate was used by the cancer cells, doesn't automatically follow that the cancer cells can use the lacate produced from exercise.

  • by melling on 8/23/24, 10:32 PM

    This is all I can read. Does the paper imply that any exercise is bad?

    “ Lactate helps cancer cells resist chemotherapy The molecule lactate is a waste product of the metabolism of sugar without oxygen — a metabolic pathway preferentially used by cancer cells to generate their energy. Metabolomics analysis reveals that lactate in tumour cells promotes resistance to chemotherapy, and sheds light on the molecular mechanism that underlies this unexpected role of lactate in cancer”

  • by valunord on 8/24/24, 12:35 AM

    It keeps coming back to metabolism being the entire key to all types of cancer.
  • by timthelion on 8/24/24, 5:59 AM

    This news should be irrelevant to anyone not undergoing this specific type of chemotherapy.
  • by thebigspacefuck on 8/24/24, 2:52 PM

    Is there a potential for beta-alanine/L-Carnosine to help here?