from Hacker News

Visualizing the inside of cells at previously impossible resolutions

by cheinyeanlim on 1/9/23, 10:58 PM with 7 comments

• by lordfrito on 1/10/23, 2:35 PM

  If you're interested in seeing images generated by this technique, a google image search of "Cryo-Electron Tomography" came up with tons of hits.

  Here's a sample of articles with images [1] [2] [3]

  Wild stuff. I never would have guessed that we'd be able to image intact cell biology at this resolution in my lifetime. Excited for the possibilities for new discoveries opened up with all these new tools/methods.

  [1] https://www.thermofisher.com/blog/atomic-resolution/whats-po...

  [2] https://www.biorxiv.org/content/10.1101/2021.07.28.454169v1....

  [3] https://www.biochem.mpg.de/5268912/20160226_Mahamid_Baumeist...

• by s1artibartfast on 1/10/23, 5:44 AM

  Article: https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.1...

• by schemescape on 1/10/23, 4:26 AM

  Are there images somewhere in the article?

  All I saw was a title image (not sure if it is real or just an artistic interpretation), and a video (with a thumbnail that looked interesting, but apparently just a bunch of people talking).

• by hoseja on 1/10/23, 11:18 AM

  >Samples are rapidly frozen to protect them from radiation damage.

  Isn't this wrong? They are rapidly frozen so the water vitrifies and permits transmission of the electron beam. The samples still get damaged by the what is basically beta radiation.

• by veilrap on 1/10/23, 2:46 AM

  For a moment I thought this article was going to be about doing visualizations of cells using Vi(m)

• by maroonblazer on 1/10/23, 1:32 AM

  vid Insights Into How They Work