from Hacker News

Tissue Nanotransfection

by justintocci on 8/7/17, 9:14 PM with 16 comments

• by justintocci on 8/7/17, 9:15 PM

  I can see the news items all over but no real information on how it works, what the mechanism is, where the papers have been published, etc https://www.bing.com/search?q=Ohio+State+device+heals+organs...

• by pimmdphd on 8/8/17, 2:21 PM

  Knowing a little inside info about this development I must add a big word of caution on this science. It may be possible to add this type of coding in an optical format, in short the code may be able to be added say to a video and when someone watches the video the optical tissues in their eyes and retina may begin to transfer into whatever form of tissue is coded. This may indeed be able to effect brain tissue by this route of administration and that is terrifying!

• by joonisboss on 8/8/17, 7:22 PM

  So I was curious about this and read the supplemental pdf, thank you justintocci. The technology hinges on Nanochannel Electroporation as the storage and delivery vehicle for the DNA. Found the following paper (scrapped the url from Wiley) that goes into detail. The potential here is insane!

  Joined Hacker News just to share it. :)

  http://onlinelibrary.wiley.com/store/10.1002/advs.201500111/...

• by 162256 on 8/8/17, 1:33 AM

  here are the supplemental data that have been released as "Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue" http://www.nature.com/nnano/journal/vaop/ncurrent/extref/nna...

• by cakra on 8/8/17, 12:58 AM

  It looks like it is being advanced as a proprietary technology and they don't want to publish on the mechanism until it is commercialized. However there is a patent http://www.google.com.pg/patents/WO2010012077A1?cl=en

• by grayzilla on 8/9/17, 4:25 AM

  David Langford had a really great FAQ about this technology over on the comp.basilisk FAQ newsgroup:

  http://ansible.uk/writing/c-b-faq.html

• by justintocci on 8/7/17, 9:19 PM

  https://www.theengineer.co.uk/tnt-tissue-regeneration/

  this gives better info of how it works but still no paper

• by justintocci on 8/7/17, 9:24 PM

  Ok, paper supposedly published here but searching finds no articles http://www.nature.com/nnano/index.html

• by 162256 on 8/8/17, 1:40 AM

  they used "projection lithography, contact photolithography, and deep reactive ion etching –DRIE- to fabricate silicon-based TNT devices.

  not clear what's proprietary.